24 Hour Customer Service:
1-570-955-1438

Call for a quote line:
1-570-301-7456

Research on Pernicious Anemia

Medical health research papers can focus on one particular condition, such as Pernicious Anemia. Our medical writers will explain any aspect of the disorder that you need focused on or do a general overview. It is all up to you to decide what you need and let our writers deliver.

This pernicious anemia research paper provides crucial information about the following:

  • Incidence
  • Prevalence
  • Symptoms
  • Diagnosis
  • Treatmen
  • Prevention of pernicious anemia

Pernicious anemia is the end stage of type A atrophic gastritis affecting the greater curvature and body of the stomach. The condition results from deficient dietary intake, or, particularly among older patients, poor absorption of vitamin B-12 (cobalamin). Pernicious anemia presents in individuals lacking the ability to produce the glycoprotein known as Castle’s intrinsic factor, which is essential for the absorption of vitamin B-12.

Pernicious Anemia

It is widely believed that the actions of autoantibodies disable secretion of the intrinsic factor by the parietal cells of the stomach. Consequently, vitamin B-12 is prevented from binding with the instrinsic factor for absorption by the distal ileum. The lesion associated with pernicious anemia may endure for 2 to 3 decades before a clinical diagnosis of the disorder is made. A relatively uncommon acquired disease, pernicious anemia usually becomes symptomatic after the age of 50 years. The disorder is most common in individuals of Northern European ancestry, particularly those originating in Scandinavia. Among individuals over the age of 60 years, approximately 1 in 100 have pernicious anemia.

In fact, however, most seemingly susceptible individuals do not develop pernicious anemia: for every person who manifests symptoms associated with the condition, there are about 10 other generally healthy individuals who never develop the clinical features associated with pernicious anemia—despite low serum concentration and impaired absorption of cobalamin, gastric atrophy, histamine-fast achlorhydria. Thus, although all patients with untreated pernicious anemia manifest with low serum cobalamin concentrations, such a finding is also fairly common among healthy individuals and is typically not associated with symptoms. Moreover, more than 50 percent of vegetarians who consume milk as their main form of animal protein present with low serum cobalamin concentrations, and low concentrations are also occasionally observed in individuals consuming a mixed diet, with normal blood counts, and normal absorption of cobalamin.

Related Research Paper Topics

Embryonic Stem Cell Research Papers examine the governments decisions on this particular research and also examnines the issues involved.

Sickle Cell Anemia - Sickle Cell Anemia Research Papers look at one of the most common inherited blood disorders.

Iron the Mineral - A deficiency of iron causes the body to produce fewer and smaller red blood cells, a condition known as anemia.

Chemotherapy - Chemotherapy Research Papers examine the side effects, and how this treatment has helped treat cancer.

Myelodysplasia - Individuals with this condition suffer from severe anemia and often require transfusions.

Hematology - Some conditions, such as iron deficiency anemia, can be easily treated.

Sjogren's Syndrome - Sickle Cell Anemia - Sickle Cell Anemia Research Papers look at one of the most common inherited blood disorders.

Chronic Illness and Ethnicity - Chronic Illness and Ethnicity research papers correlate race and ethnic heritage with medical health aspects of disease.